TABLE 4

Summary of KZR-616 and proposed metabolites observed in human plasma

Component LabelIdentificationRetention Time[M+H]+Component in Plasma as % of Total aXIC Area
Subject
110-004112-021113-002116-012
minm/z
KZR-616Parent22.0587.361.249.046.551.8
KZR-59587Epoxide hydrolysis16.4605.333.845.847.943.8
M605_2Epoxide hydrolysis (isomer)14.5605.30.2700.2700.2700.280
M603_1Oxidation11.0603.30.0800.1000.0600.060
M603_7Oxidation11.8603.30.1000.2500.0400.170
M603_8Oxidation13.3603.30.1500.1900.1500.190
M603_2Oxidation15.0603.30.0800.0200.0800.060
M603_3Oxidation17.5603.30.1400.1100.1500.100
M603-4Hydrolysis + dehydrogenation20.2603.30.2800.4200.2900.240
M603_5Hydrolysis + dehydrogenation20.4603.30.2600.2600.2800.240
M603_6Oxidation22.8603.30.3900.3400.4100.330
M601Oxidation + dehydrogenation14.4601.30.8900.8700.8000.910
M619_1Double oxidation9.71619.30.2800.2800.1600.190
M619_2Double oxidation19.1619.30.1200.1700.0300.020
  • aXIC, extracted-ion chromatogram in LC-MS analysis.