TABLE 2

PK parameters of KZR-616 and analogs after a single subcutaneous dose at 3 mg/kg in monkeys

IDKZR-59177KZR-616KZR-59240
t1/2 (h)1.44 ± 0.4201.05 ± 0.1300.980 ± 0.264
Tmax (h)0.792 ± 0.4170.333 ± 0.1360.500 ± 0.334
Cmax (ng/ml)182 ± 31.5441 ± 114803 ± 260
AUCinf (h*ng/ml)447 ± 57.3740 ± 1881412 ± 279
AUC ratio (diol/parent)3.35 ± 1.203.40 ± 0.8080.777 ± 0.464
% Unbound fractionNA42.2NA
  • AUCinf, area under the curve from zero to infinity.