TABLE 1

Efflux ratios of 11-OH-THC and THC-COOH in MDCKII-P-gp cells in Transwell transport assays

Data shown are means ± S.D. of three independent experiments with triplicate in each experiment. ER was calculated as the ratio of individual P_{app, B→A} to its corresponding P_{app, B→A}. Differences in ERs between DMSO and tariquidar in each treatment group were analyzed by the paired Student’s t test. ER of THC is not shown here because THC could not be detected in the receiver compartment (see Results for details).

Group	Compound	Treatment	ER	Level of Significance
11-OH-THC (n = 3)	0.3 µM 11-OH-THC	DMSO	0.98 ± 0.46	NS
	0.3 µM 11-OH-THC	5 µM tariquidar	0.90 ± 0.42	NS
	2 µM Quinidine	DMSO	10.69 ± 7.45	P = 0.0473
	2 µM Quinidine	5 µM tariquidar	1.01 ± 0.35	P = 0.0473
THC-COOH (n = 3)	2.5 µM THC-COOH	DMSO	1.04 ± 0.40	NS
	2.5 µM THC-COOH	5 µM tariquidar	0.74 ± 0.05	NS
	2 µM Quinidine	DMSO	6.01 ± 1.13	P = 0.0050
	2 µM Quinidine	5 µM tariquidar	1.26 ± 0.12	P = 0.0050