Identity of drug-metabolizing enzymes and transporters positively identified in EV isolated from human biofluids
| Family | Enzyme | Protein Reported | Reference | mRNA Reported | Reference |
|---|---|---|---|---|---|
| P450 | 1A1 | Yes | (Kumar et al., 2017) | ||
| 1A2 | Yes | (Rowland et al., 2019) | Yes | (Rowland et al., 2019; Achour et al., 2021) | |
| 2A6 | Yes | (Kumar et al., 2017) | Yes | (Kumar et al., 2017) | |
| 2B1 | Yes | (Kumar et al., 2017) | Yes | (Kumar et al., 2017) | |
| 2B6 | Yes | (Rowland et al., 2019) | |||
| 2C8 | Yes | (Rowland et al., 2019) | Yes | (Rowland et al., 2019) | |
| 2C9 | Yes | (Rowland et al., 2019) | Yes | (Rowland et al., 2019; Achour et al., 2021) | |
| 2C19 | Yes | (Rowland et al., 2019) | Yes | (Achour et al., 2021) | |
| 2D6 | Yes | (Rowland et al., 2019; Moon et al., 2011) | Yes | (Achour et al., 2021) | |
| 2E1 | Yes | (Rowland et al., 2019; Kumar et al., 2017) | Yes | (Rowland et al., 2019; Kumar et al., 2017) | |
| 2J2 | Yes | (Rowland et al., 2019) | |||
| 3A4 | Yes | (Rowland et al., 2019; Rodrigues et al., 2021; Kumar et al., 2017) | Yes | (Rowland et al., 2019; Kumar et al., 2017; Achour et al., 2021) | |
| 3A5 | Yes | (Rowland et al., 2019) | Yes | (Achour et al., 2021) | |
| UGT | 1A1 | Yes | (Rowland et al., 2019) | Yes | (Rowland et al., 2019; Achour et al., 2021) |
| 1A3 | Yes | (Rowland et al., 2019) | |||
| 1A4 | Yes | (Rowland et al., 2019) | |||
| 1A6 | Yes | (Rowland et al., 2019) | |||
| 1A9 | Yes | (Rowland et al., 2019) | Yes | (Rowland et al., 2019; Achour et al., 2021) | |
| 2B4 | Yes | (Rowland et al., 2019) | Yes | (Rowland et al., 2019; Achour et al., 2021) | |
| 2B7 | Yes | (Rowland et al., 2019) | Yes | (Rowland et al., 2019; Achour et al., 2021) | |
| 2B10 | Yes | (Rowland et al., 2019) | Yes | (Rowland et al., 2019) | |
| 2B15 | Yes | (Rowland et al., 2019) | Yes | (Rowland et al., 2019) | |
| OATP | 1B1 | Yes | (Rodrigues et al., 2021) | Yes | (Achour et al., 2021) |
| 1B3 | Yes | (Rodrigues et al., 2021) | |||
| ABC | B1 | Yes | (Achour et al., 2021) | ||
| G2 | Yes | (Achour et al., 2021) | |||
| C2 | Yes | (Achour et al., 2021) |