Metabolite | Description | Percentage of Dose Administered to Group 1 | Percentage of Dose Administered to Group 2 | |||
---|---|---|---|---|---|---|
Urine (0–144 h) | Feces (0–168 h)a | Urine (0–48 h) | Feces (0–48 h) | Bile (0–24 h) | ||
M15 | Loss of chlorine + cysteine conjugate | ND | ND | ND | ND | 1.42 |
M1 | Glucuronide conjugate to M4 | 2.16 | ND | 1.19 | ND | ND |
M7 | Glucuronide conjugate to M4 | 2.62 | ND | 1.14 | ND | 3.77 |
M16 | Glucuronide conjugate to M4 | 0.297 | ND | ND | ND | 0.992 |
M17b | Glucuronide conjugate to M4 | 0–1.85 | ND | 0–0.596 | ND | 0–1.83 |
M2b | Loss of ribose + glucuronide | 0–1.85 | ND | 0–0.596 | 0.0282 | 0–1.83 |
M10 | Glucuronide conjugate to parent | 0.402 | ND | ND | ND | ND |
M4 | Loss of propyl | 2.0 | 8.80–9.34 | 0.678 | 0.511 | ND |
M5 | Oxidation on propyl | ND | 0.416–0.433 | 0.0457 | ND | ND |
M11 | Glucuronide conjugate to parent | 1.2 | ND | 0.334 | ND | 34.2 |
M12 | Glucuronide conjugate to parent | 2.01 | ND | 0.551 | ND | 38.6 |
Maribavir | Parent | 0.823 | 57.9–60.3 | 0.224 | 1.45 | 1.26 |
ND, not detected or below the limit of quantitation (1% of run and 10 cpm peak height).
aThe lower dose percentage value was based on pooled fecal samples from all three animals from 0 to 120 hours. Only one animal generated feces from 120 to 168 hours; the upper value reflected the addition of dose percentage from this single animal after 120 hours to the group’s pre–120-hour value.
bWhen M17 and M2 are both present in the same matrix, they are indistinguishable in the radio and ion chromatogram as a single peak. Dose percentage values derived from this combined peak were therefore reported.