TABLE 2

Noncompartmental PK parameters for radioactivity in plasma collected from male cynomolgus monkeys after a single intravenous administration of 14C-maribavir (both groups at 13 mg/kg). Group 1: intact monkeys (n = 3), group 2: BDC monkeys (n = 3)

PK Parameter on Total Radioactivity in PlasmaGroup 1 (Intact),
Mean ± S.D.
Group 2 (BDC),
Mean ± S.D.
AUC0–t (ng maribavir equivalent·h/g)28,000 ± 577017,100 ± 4050
AUC0–∞ (ng maribavir equivalent·h/g)30,300 ± 590017,900 ± 3470
t1/2 (h)19.7 ± 3.42.71 ± 1.4
CL (g/h)1700 ± 3473010 ± 528
Vss (g)27,700 ± 39106010 ± 1110
  • AUC0–t, area under the conc.-time curve from time 0 to the last measurable time point; AUC0–∞, area under the conc.-time curve from zero to infinity; CL, clearance; Vss, volume of distribution at steady state.