PK Parameter on Maribavir Concentration in Plasma | Group 1 (Intact), Mean ± S.D. | Group 2 (BDC), Mean ± S.D. |
---|---|---|
AUC0–t (h·mg/l) | 17.4 ± 3.9 | 9.33 ± 1.7 |
AUC0–∞ (h·mg/l) | 17.4 ± 3.9 | 9.36 ± 1.6 |
C0 (mg/l) | 9.96a | 10.4 ± 1.3 |
t1/2 (h) | 12.5 ± 1.1 | 2.49 ± 1.2 |
CL (l/h) | 2.99 ± 0.73 | 5.72 ± 0.90 |
Vss (l) | 35.4 ± 6.5 | 7.09 ± 1.5 |
AUC0–t, area under the conc.-time curve from time 0 to the last measurable time point; AUC0–∞, area under the conc.-time curve from zero to infinity; C0, initial conc.; CL, clearance; Vss, volume of distribution at steady state.
aFor C0, only two animals in group 1 were involved in calculating the mean because of one animal missing the 5-minute PK time point.