AUC ratios of isoflavone sulfates after oral administration of febuxostat in micea
*P < 0.05; **P < 0.01, significantly different from the vehicle group (one-way ANOVA followed by Dunnett's post hoc test).
| Compounds | Treatment | Cmax | AUC(0-7) | AUC Ratio |
|---|---|---|---|---|
| ng/ml | ng•h/ml | |||
| Sulfasalazine | Vehicle | 3.34 × 102 ± 1.03 × 102 | 6.07 × 102 ± 1.08 × 102 | - |
| Febuxostat 30 mg/kg | 1.16 × 103 ± 0.22 × 103 | 2.27 × 103 ± 0.55 × 103 | 3.74 | |
| Febuxostat 90 mg/kg | 1.83 × 103 ± 0.91 × 103 ** | 3.80 × 103 ± 2.18 × 103 * | 6.27 | |
| DS | Vehicle | 1.70 × 103 ± 0.64 × 103 | 5.43 × 103 ± 1.76 × 103 | – |
| Febuxostat 30 mg/kg | 1.85 × 103 ± 1.20 × 103 | 7.15 × 103 ± 0.92 × 103 | 1.32 | |
| Febuxostat 90 mg/kg | 2.35 × 103 ± 1.22 × 103 | 9.80 × 103 ± 5.44 × 103 | 1.80 | |
| GS | Vehicle | 1.22 × 102 ± 0.50 × 102 | 2.79 × 102 ± 1.46 × 102 | – |
| Febuxostat 30 mg/kg | 1.98 × 102 ± 0.67 × 102 | 6.59 × 102 ± 0.84 × 102 | 2.36 | |
| Febuxostat 90 mg/kg | 2.86 × 102 ± 1.48 × 102 | 1.15 × 103 ± 0.73 × 103 * | 4.11 | |
| ES | Vehicle | 0.67 × 102 ± 0.36 × 102 | 4.28 × 102 ± 0.76 × 102 | – |
| Febuxostat 30 mg/kg | 5.06 × 102 ± 3.64 × 102 | 2.39 × 103 ± 1.59 × 103 | 5.60 | |
| Febuxostat 90 mg/kg | 4.53 × 102 ± 3.75 × 102 | 2.07 × 103 ± 1.48 × 103 | 4.83 |
aMean ± S.D. (n = 4).