TABLE 1

fu,mic values obtained by HLM-beads and RED methods

HLMs (mg/ml)0.0250.501.0
Compoundfu,micfu,micfu,mic
HLM-beadsREDHLM-beadsREDHLM-beadsRED
AcidicDiclofenac0.94 (0.09)a0.98 (0.02)0.960.92 (0.03)0.93 (0.04)0.990.87 (0.17)0.83 (0.08)1.0
Warfarin1.02 (0.01)0.97 (0.05)1.11.02 (0.04)0.94 (0.03)1.10.97 (0.03)0.86 (0.08)1.1
Tolbutamide0.93 (0.07)0.98 (0.02)0.961.01 (0.04)0.98 (0.03)1.00.92 (0.04)0.97 (0.03)0.95
NeutralAlprazolam0.81 (0.06)0.98 (0.14)0.820.78 (0.06)1.0 (0.1)0.770.68 (0.07)1.0 (0.1)0.66
Diazepam1.0 (0.1)0.96 (0.01)1.10.82 (0.07)0.77 (0.02)1.10.66 (0.03)0.64 (0.02)1.0
Itraconazole0.24 (0.04)0.29 (0.07)0.840.10 (0.01)0.036 (0.005)2.80.073 (0.004)0.025 (0.001)2.9
Midazolam1.02 (0.01)0.98 (0.14)1.00.76 (0.02)0.67 (0.06)1.10.53 (0.02)0.52 (0.08)1.0
BasicChlorpromazineb0.79 (0.13)0.71 (0.02)1.10.11 (0.02)0.084 (0.005)1.40.056 (0.006)0.0437 (0.0003)1.3
Clozapine0.96 (0.06)0.87 (0.06)1.10.48 (0.01)0.42 (0.051.10.26 (0.02)0.30 (0.02)0.85
Diltiazem0.99 (0.04)0.96 (0.03)1.01.2 (0.1)0.77 (0.09)1.50.97 (0.03)0.76 (0.12)1.3
Imipramineb0.94 (0.04)0.94 (0.04)0.990.35 (0.01)0.40 (0.03)0.880.19 (0.01)0.26 (0.01)0.71
Verapamil1.0 (0.1)1.0 (0.1)1.00.59 (0.04)0.56 (0.05)1.10.32 (0.03)0.43 (0.06)0.74
BIRT2584b0.43 (0.04)0.42 (0.05)1.00.064 (0.021)0.024 (0.003)2.70.035 (0.004)0.019 (0.002)1.9
  • aValues represent the mean (standard deviation) from triplicate determination.

  • bData obtained using presoaked RED membranes.