TABLE 1

Different cases for sigmoidal kinetics

The cases k2 > k5 (Km1 > Km2) and k6 > k3 = 0 (kcat1 > kcat2 > 0) are not discussed.

ParameterCase ICase IICase IIICase IV
k2, k5
(Km1, Km2)
k2 > k5
(Km1 > Km2)
k2 = k5
(Km1 = Km2)
k2 > k5
(Km1 > Km2)
k2 = k5
(Km1 = Km2)
k3, k6
(kcat1, kcat2)
k6 = k3
(kcat1 = kcat2 > 0)
k6 > k3
(kcat2 > kcat1 > 0)
k6 > k3 = 0
(kcat2 > kcat1 = 0)
k6 > k3 = 0
(kcat2 > kcat1 = 0)