TABLE 4

Prediction of P450-mediated clinical drug interaction potential after oral or inhaled dose of THC or CBD^a

	THC			11-OH-THC			THC-COO-Gluc			CBD
	Oral		Inhaled	Oral		Inhaled	Oral		Inhaled	Oral		Inhaled
Enzyme	AUCR_hep	AUCR_sys	AUCR_sys	AUCR_hep	AUCR_sys	AUCR_sys	AUCR_hep	AUCR_sys	AUCR_sys	AUCR_hep	AUCR_sys	AUCR_sys
CYP1A2	1.25	1.02	1.08		NA^b			NA		7.38	1.20	1.09
CYP3A4		NA			NA			NA		9.24	1.26	1.11
CYP2B6	1.09	1.01	1.03	1.32	1.03	1.02	1.08	1.03	1.03	12.26	1.35	1.15
CYP2C9	1.31	1.03	1.10	1.44	1.04	1.03	1.05	1.02	1.02	9.24	1.26	1.11
CYP2C19	1.40	1.03	1.13		NA			NA		16.32	1.48	1.21
CYP2D6	1.20	1.02	1.07	1.17	1.02	1.02	1.08	1.03	1.03	11.94	1.34	1.15
CYP2E1		NA			NA			NA		37.47	2.14	1.49

↵^aThe AUCR_hep and AUCR_sys were calculated for THC, 11-OH-THC and THC-COO-Gluc based on oral or inhaled dosing of THC; the AUCR_hep and AUCR_sys were calculated for CBD based on oral or inhaled dosing of CBD as described in Materials and Methods.
↵^bNA, not analyzed.