Comparison of model fits
| Performance | HHEPs | HLM | HLM | HLM | HHEPs | HLM | HHEPs | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| R2 x 3 | Model 1 | Model 2 | Model 3 | R1 | R2 x 3 | Model 1 (Reversible Inhibition Only) | Model 1 (Same Data-Set) | Model 3 (Same Data-Set) | |||
| GMFE (90% CI) | 9.42 (8.75–10.1) | 1.12 (0.89–1.34) | 1.16 (0.9–1.4) | 0.90 (0.70–1.14) | 0.55 (0.22–0.88) | 4.02 (3.26–4.78) | 0.475 (0.21–0.74) | 0.98 (0.67–1.30) | 1.0 (0.71–1.35) | 0.67 (0.26–1.07) | 0.84 (0.46–1.21) |
| RMSE | 284 | 2.76 | 3.63 | 3.67 | 17.3 | 5.28 | 16.5 | 1.04 | 0.426 | 2.71 | 0.508 |
| % within bioequivalence (0.8–1.25) | 2.7 | 53.8 | 48.7 | 45.4 | 13.9 | 3.0 | 15.1 | 53.0 | 57.6 | 48.5 | 56.1 |
| % within twofold | 14.3 | 91.6 | 90.8 | 84.9 | 52.2 | 10.6 | 50.4 | 87.9 | 89.4 | 68.2 | 74.2 |
| % within threefold | 21.4 | 97.5 | 97.5 | 98.3 | 73.9 | 34.8 | 75.6 | 97.0 | 95.5 | 80.3 | 86.4 |
| # over twofold | 96 | 7 | 8 | 3 | 6 | 50 | 1 | 4 | 4 | 2 | 4 |
| # below twofold | 0 | 3 | 3 | 15 | 49 | 9 | 58 | 4 | 3 | 19 | 13 |
| # of FN | 2 | 0 | 0 | 3 | 13 | 0 | 44 | 0 | 0 | 13 | 3 |
Model 1 incorporates the reported inhibitor specific parameters to derive the unbound hepatic inlet concentration, whereas Model 1 default inputs Ka = 0.03 min−1 and Fa:Fg = 1, and Model 2 incorporates the Cmax,ss,u into the equation rather than hepatic inlet concentration.