TABLE 5

The effect of protein addition on hepatocyte predictability within twofold observed for CLH, b (or CLH, p) by high solubility BDDCS class 1 and 3 drugs and low solubility BDDCS class 2 and 4 drugs

Predicted/Observed CLH, bPredicted/Observed CLH, p
Without SerumWith SerumWithout SerumWith Serum
Over TwofoldWithin TwofoldOver TwofoldWithin TwofoldOver TwofoldWithin TwofoldOver TwofoldWithin Twofold
BDDCS class1 and 360.5%(n = 26 of 43)39.5%(n = 17 of 43)56.8%(n = 25 of 44)43.2%(n = 19 of 44)70.1%(n = 34 of 43)20.9%(n = 9 of 43)79.5%(n = 35 of 44)20.5%(n = 9 of 44)
BDDCS class2 and 488.6%(n = 22 of 28)21.4%(n = 6 of 28)52.1%(n = 18 of 29)37.9%(n = 11 of 29)87.5%(n = 21 of 24)12.5%(n = 3 of 24)60.0%(n = 15 of 25)40.0%(n = 10 of 25)