TABLE 2

The effect of protein addition on microsome clearance predictability within twofold of observed CLH, b (or CLH, p) for all drugs and separated for low (≤0.3), intermediate (>0.3–<0.7), and high (≥0.7) extraction ratio drugs

Predicted/Observed CLH,bPredicted/Observed CLH,p
Without SerumWith SerumWithout SerumWith Serum
Over TwofoldWithin TwofoldOver TwofoldWithin TwofoldOver TwofoldWithin TwofoldOver TwofoldWithin Twofold
All drugs79.2%(n = 19 of 24)20.8%(n = 5 of 24)62.5%(n = 15 of 24)37.5%(n = 9 of 24)79.2%(n = 19 of 24)20.8%(n = 5 of 24)66.7%(n = 16 of 24)33.3%(n = 8 of 24)
Low ER75.0%(n = 6 of 8)25.0%(n = 2 of 8)75.0%(n = 6 of 8)25.0%(n = 2 of 8)75.0%(n = 6 of 8)25.0%(n = 2 of 8)62.5%(n = 5 of 8)37.5%(n = 3 of 8)
Moderate ER71.4%(n = 5 of 7)28.6%(n = 2 of 7)57.1%(n = 4 of 7)42.9%(n = 3 of 7)40.0%(n = 2 of 5)60.0%(n = 3 of 5)0.00%(n = 0 of 5)100%(n = 5 of 5)
High ER88.9%(n = 8 of 9)11.1%(n = 1 of 9)55.6%(n = 5 of 9)44.4%(n = 4 of 9)100%(n = 11 of 11)0.00%(n = 0 of 11)100%(n = 11 of 11)0.00%(n = 0 of 11)