TABLE 9

Analysis of reported data from hepatocyte and microsomal incubations for comparison of the change of predicted in vivo CLint (CLint, in vitro, with protein/CLint, in vitro, without protein) in terms of BDDCS class.

CLint,in vivo,with protein/CLint,in vivo,without protein
AllDecreaseIncrease < TwofoldIncrease > Twofold
HepatocytesAll drugs7342.5% (31 of 73)15.1% (11 of 73)42.5% (31 of 73)
BDDCS class 14151.2% (21 of 41)17.1% (7 of 41)31.7% (13 of 41)
BDDCS class 22733.3% (9 of 27)11.1% (3 of 27)55.6% (15 of 27)
BDDCS class 3333.3% (1 of 3)33.3% (1 of 3)33.3% (1 of 3)
BDDCS class 420.00% (0 of 2)0.00% (0 of 2)100% (2 of 2)
MicrosomesAll drugs2412.5% (3 of 24)20.8% (5 of 24)66.7% (16 of 24)
BDDCS class 1714.3% (1 of 7)42.9% (3 of 7)42.9% (3 of 7)
BDDCS class 21711.8% (2 of 17)11.8% (2 of 17)76.5% (13 of 17)