TABLE 8

The effect of protein addition on microsome predictability within twofold observed for CLH, b (or CLH, p) by drugs categorized as acids, bases, neutrals, or zwitterions

Predicted/Observed CLH, bPredicted/Observed CLH, p
Without SerumWith SerumWithout SerumWith Serum
Over TwofoldWithin TwofoldOver TwofoldWithin TwofoldOver TwofoldWithin TwofoldOver TwofoldWithin Twofold
Acids75.0%(n = 9 of 12)25.0%(n = 3 of 12)50.0%(n = 6 of 12)50.0%(n = 6 of 12)66.7%(n = 8 of 12)33.3%(n = 4 of 12)50.0%(n = 6 of 12)50.0%(n = 6 of 12)
Bases0.00%(n = 0 of 1)100%(n = 1 of 1)0.00%(n = 0 of 1)100%(n = 1 of 1)0.00%(n = 0 of 1)100%(n = 1 of 1)0.00%(n = 0 of 1)100%(n = 1 of 1)
Neutrals88.9%(n = 8 of 9)11.1%(n = 1 of 9)88.9%(n = 8 of 9)11.1%(n = 1 of 9)100%(n = 9 of 9)0.00%(n = 0 of 9)88.9%(n = 8 of 9)11.1%(n = 1 of 9)
Zwitterions100%(n = 2 of 2)0.00%(n = 0 of 2)100%(n = 2 of 2)0.00%(n = 0 of 2)100%(n = 2 of 2)0.00%(n = 0 of 2)100%(n = 2 of 2)0.00%(n = 0 of 2)