TABLE 7

The effect of protein addition on hepatocyte predictability within twofold observed for CLH, b (or CLH, p) by drugs categorized as acids, bases, neutrals, or zwitterions

Predicted/Observed CLH, bPredicted/Observed CLH, p
Without SerumWith SerumWithout SerumWith Serum
Over TwofoldWithin TwofoldOver TwofoldWithin TwofoldOver TwofoldWithin TwofoldOver TwofoldWithin Twofold
Acids88.9%(n = 16 of 18)11.1%(n = 2 of 18)68.4%(n = 13 of 19)31.6%(n = 6 of 19)94.1%(n = 16 of 17)5.9%(n = 1 of 17)66.7%(n = 12 of 18)33.3%(n = 6 of 18)
Bases54.8%(n = 17 of 31)45.2%(n = 14 of 31)53.1%(n = 17 of 32)46.9%(n = 15 of 32)77.4%(n = 24 of 31)22.6%(n = 7of 31)71.9%(n = 23 of 32)28.1%(n = 9 of 32)
Neutrals75.0%(n = 13 of 20)35.0%(n = 7 of 20)60.0%(n = 12 of 20)40.0%(n = 8 of 20)76.5%(n = 13 of 17)23.5%(n = 4 of 17)82.4%(n = 14 of 17)17.6%(n = 3 of 17)
Zwitterions100%(n = 2 of 2)0.00%(n = 0 of 2)50.0%(n = 1 of 2)50.0%(n = 1 of 2)100%(n = 2 of 2)0.00%(n = 0 of 2)50.0%(n = 1 of 2)50.0%(n = 1 of 2)