TABLE 3

The effect of protein addition on the hepatocyte predictability within twofold of observed CLH, b (or CLH, p) for all drugs and separated by protein-binding category

Predicted/Observed CLH,bPredicted/Observed CLH,p
Without SerumWith SerumWithout SerumWith Serum
Over TwofoldWithin TwofoldOver TwofoldWithin TwofoldOver TwofoldWithin TwofoldOver TwofoldWithin Twofold
All drugs67.6%(n = 48 of 71)32.4%(n = 23 of 71)58.9%(n = 43 of 73)41.1%(n = 30 of 73)82.1%(n = 55 of 67)17.9%(n = 12 of 67)72.5%(n = 50 of 69)27.5%(n = 19 of 69)
fu < 0.185.3%(n = 29 of 34)14.7%(n = 5 of 34)60.0%(n = 21 of 35)40.0%(n = 14 of 35)91.2%(n = 31 of 34)8.82%(n = 3 of 34)62.9%(n = 22 of 35)37.1%(n = 13 of 35)
fu > 0.151.4%(n = 19 of 37)48.6%(n = 18 of 37)57.9%(n = 22 of 38)42.1%(n = 16 of 38)72.7%(n = 24 of 33)27.3%(n = 9 of 33)82.4%(n = 28 of 34)17.6%(n = 6 of 34)