TABLE 4

The effect of protein addition on the microsome predictability within twofold of observed CLH, b (or CLH, p) for all drugs and separated by protein-binding category

Predicted/Observed CLH, bPredicted/Observed CLH, p
Without SerumWith SerumWithout SerumWith Serum
Over TwofoldWithin TwofoldOver TwofoldWithin TwofoldOver TwofoldWithin TwofoldOver TwofoldWithin Twofold
All drugs79.2%(n = 19 of 24)20.8%(n = 5 of 24)62.5%(n = 15 of 24)37.5%(n = 9 of 24)79.2%(n = 19 of 24)20.8%(n = 5 of 24)66.7%(n = 16 of 24)33.3%(n = 8 of 24)
fu < 0.171.4%(n = 10 of 14)28.6%(n = 4 of 14)71.4%(n = 10 of 14)28.6%(n = 4 of 14)64.3%(n = 9 of 14)35.7%(n = 5 of 14)71.4%(n = 10 of 14)28.6%(n = 4 of 14)
fu > 0.190.0%(n = 9 of 10)10.0%(n = 1 of 10)50.0%(n = 5 of 10)50.0%(n = 5 of 10)100%(n = 10 of 10)0.00%(n = 0 of 10)70.0%(n = 7 of 10)30.0%(n = 3 of 10)