TABLE 6

The effect of protein addition on microsome predictability within twofold observed for CLH, b (or CLH, p) by high solubility BDDCS class 1 drugs and low solubility BDDCS class 2 drugs

Predicted/Observed CLH, bPredicted/Observed CLH, p
Without SerumWith SerumWithout SerumWith Serum
Over TwofoldWithin TwofoldOver TwofoldWithin TwofoldOver TwofoldWithin TwofoldOver TwofoldWithin Twofold
BDDCSclass 171.4%(n = 5 of 7)28.6%(n = 2 of 7)42.9%(n = 3 of 7)57.1%(n = 4 of 7)85.7%(n = 6 of 7)14.3%(n = 1 of 7)85.7%(n = 6 of 7)14.3%(n = 1 of 7)
BDDCSclass 282.4%(n = 14 of 17)17.6%(n = 3 of 17)70.6%(n = 12 of 17)29.4%(n = 5 of 17)66.5%(n = 13 of 17)23.5%(n = 4 of 17)58.8%(n = 10 of 17)41.2%(n = 7 of 17)