Main differences between human and mouse BAs
| Human BAs | Mouse BAs |
|---|---|
| Primary BAs: CA and CDCA. | Primary BAs: CA, α-MCA, and β-MCA. |
| UDCA: Not a primary BA. | UDCA: Is a minor primary BA. |
| Conjugate: Both glycine and taurine conjugates. | Conjugate: Essentially taurine conjugates only. |
| 6β-hydroxylation: Does not happen. | 6β-hydroxylation: Catalyzed by Cyp2c70 to form α-MCA and β-MCA. |
| Interaction with FXR: CA and CDCA are agonists. | Interaction with FXR: MCAs are antagonists. |