AhR | CAR | CAR | PXR | PXR | PPARα | PPARα | Nrf2 | Nrf2 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Males AhR- ag/WT | Females AhR-ag/WT | Males CAR-null/WT | Males CARag/WT | Females CAR-null/WT | Females CARag/WT | Males PXR null/WT | Males PXRag/WT | Females PXR null/WT | Females PXRag/WT | Males PPAR null/WT | Males PPA Rag/WT | Females PPAR null/WT | Females PPAR ag/WT | Males Nrf2 null/WT | Males Nrf-ag/WT | Females Nrf-null/WT | Females Nrf-ag/ WT | ||
Bile acids | S BA CONC | 79 | 125 | 100 | 100 | 100 | 100 | 25 | 29 | 51 | 76 | 56 | 51 | 100 | 100 | 100 | 100 | 100 | 100 |
L BA CONC | 44 | 57 | 65 | 51 | 65 | 94 | 91 | 64 | 57 | 75 | 73 | 59 | 100 | 66 | 55 | 60 | 100 | 66 | |
Bil exc | 122 | 100 | 100 | 100 | 100 | 100 | 93 | 73 | 70 | 93 | 165 | 201 | 100 | 100 | 100 | 142 | 100 | 100 | |
liver mRNA | L-SHP | 100 | 74 | 88 | 373 | 100 | 100 | 202 | 312 | 45 | 50 | 100 | 100 | 100 | 100 | 22 | 152 | 100 | 100 |
L-FXR | 100 | 100 | 100 | 274 | 100 | 100 | 129 | 184 | 90 | 85 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | |
L-CYP7A1 | 100 | 94 | 100 | 285 | 224 | 100 | 35 | 150 | 178 | 105 | 100 | 100 | 172 | 67 | 100 | 100 | 172 | 67 | |
L-CYP7B1 | 28 | 76 | 100 | 39 | 95 | 26 | 86 | 91 | 249 | 79 | 57 | 37 | 61 | 178 | 100 | 100 | 61 | 178 | |
L-CYP8B1 | 32 | 26 | 100 | 29 | 100 | 100 | 179 | 165 | 117 | 115 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | |
L-NTCP | 100 | 77 | 100 | 322 | 100 | 67 | 215 | 266 | 92 | 106 | 100 | 144 | 100 | 100 | 162 | 132 | 100 | 100 | |
L-OATP1B2 | 100 | 67 | 100 | 232 | 100 | 79 | 141 | 205 | 88 | 84 | 100 | 151 | 100 | 100 | 158 | 175 | 100 | 100 | |
L-BSEP | 100 | 79 | 100 | 236 | 78 | 74 | 201 | 234 | 78 | 88 | 100 | 126 | 100 | 100 | 152 | 134 | 100 | 100 | |
ileum mRNA | I-SHP | 600 | 195 | 100 | 100 | 100 | 462 | 82 | 151 | 383 | 194 | 40 | 27 | 100 | 600 | 22 | 34 | 100 | 600 |
I-FXR | 100 | 93 | 100 | 100 | 100 | 100 | 67 | 117 | 116 | 107 | 80 | 63 | 100 | 100 | 100 | 100 | 100 | 100 | |
I-FGF15 | 194 | 75 | 100 | 100 | 100 | 100 | 163 | 231 | 182 | 86 | 100 | 23 | 49 | 194 | 44 | 100 | 49 | 194 | |
I-ASBT | 100 | 85 | 60 | 100 | 100 | 100 | 60 | 98 | 103 | 127 | 100 | 63 | 100 | 100 | 48 | 44 | 100 | 100 | |
I-BABP | 219 | 78 | 100 | 100 | 100 | 100 | 187 | 116 | 131 | 160 | – | – | – | – | – | – | – | – | |
I-OST-α | 204 | 133 | 100 | 100 | 100 | 100 | 82 | 92 | 191 | 139 | – | – | – | – | – | – | – | – | |
I-OST-β | 78 | 83 | 100 | 100 | 100 | 100 | 83 | 151 | 383 | 194 | 77 | 67 | 154 | 100 | 100 | 61 | 150 | 100 | |
I-ABCG5 | 100 | 100 | 100 | 100 | 100 | 100 | 69 | 135 | 139 | 96 | 100 | 61 | 100 | 125 | 77 | 62 | 100 | 125 | |
I-ABCG8 | 100 | 100 | 100 | 100 | 100 | 100 | 91 | 156 | 130 | 92 | 100 | 57 | 100 | 157 | 100 | 74 | 100 | 157 |