TABLE 2

Studies focused on the role of Nrf2 in skin allergy

DiseaseModelEffect of Nrf2-KnockoutReferences
Atopic DermatitisBALB/cWT & Nrf2 (−/−)↓ Ear thickness; ↓ effector cell infiltration, ↓ type 2 cytokine, ↓ IgE response(Ogawa et al., 2020b)
Contact DermatitisEx vivo: BMDC Nrf2 (+/+) versus (−/−)↓ Expression of antioxidant genes(Mussotter et al., 2016)
C57BL/6WT & Nrf2(−/−)↑ PMN recruitment to skin during sensitization phase(Helou et al., 2019)
C57BL/6WT & Nrf2(−/−)↑ Ear thickness(El Ali et al., 2013; Helou et al., 2019)
  • IgE, immunoglobulin E.