TABLE 1

Drug metabolism–related genes whose mRNA is subjected to A-to-I RNA editing and expression is regulated by ADARs

GeneA-to-I RNA EDITED REGIONEffects, ADARs, Cell LineReference
Evaluation by NGSaEvaluation by Sanger Sequencing
CYP1A2Intron, 3′-UTRNDUpregulation, ADAR2, HepaRG cellsNozaki et al., 2019
CYP2A6IntronNDUpregulation, ADAR1 and ADAR2, HepaRG cellsNozaki et al., 2019
CYP2B6Intron, 3′-UTRNot edited in 3′-UTRUpregulation, ADAR1 and ADAR2, HepaRG cellsNozaki et al., 2019
CYP2C85′-UTR, intronNDUpregulation, ADAR1 and ADAR2, HepaRG cellsNozaki et al., 2019
CYP2C9Intron, 3′-UTRNDUpregulation, ADAR1 and ADAR2, HepaRG cellsNozaki et al., 2019
CYP2C193′-UTRNDUpregulation, ADAR1 and ADAR2, HepaRG cellsNozaki et al., 2019
CYP2D6Coding regionNDUpregulation, ADAR2, HepaRG cellsNozaki et al., 2019
CYP2E1IntronNDUpregulation, ADAR1 and ADAR2, HepaRG cellsNozaki et al., 2019
CYP3A4Intron, 3′-UTRNot edited in 3′-UTRDownregulation, ADAR1, HepaRG and HepG2 cellsNozaki et al., 2019; Takemoto et al., 2021b
UGT1AIntron, 3′-UTRNDDownregulation, ADAR1, HepG2 cellsTakemoto et al., 2021b
UGT2B4IntronNDND
UGT2B15IntronNDND
UGT2B17IntronNDND
CES1IntronNDND
CES25′-UTR, intronNDND
AhR3′-UTREdited in 3′-UTRDownregulation, ADAR1, Huh-7 cellsNakano et al., 2016
CARIntronNot edited in intronDownregulation, ADAR1, HepG2 cellsNakano et al., 2019
HNF4αIntronNDUpregulation, ADAR1 and ADAR2, HepaRG and Huh-7cellsNozaki et al., 2019
PXRIntronNot edited in 3′-UTRDownregulation, ADAR1 and ADAR2, HepaRG and HepG2 cellsTakemoto et al., 2021b