400 mg Once Daily | 600 mg Once Daily | 600 mg Once Daily | Reference | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Parameters | Observed | Predicted | Ratio | Observed | Predicted | Ratio | Observed | Predicted | Ratio | ||
Efavirenz | N | 311 | 295 | 11 | Villani et al., 1999; Dickinson et al., 2016 | ||||||
AUClast (mg.h/l) | 49.20 | 51.81 | 1.05 | 67.20 | 70.97 | 1.06 | 57.15 | 70.84 | 1.24 | ||
Cmax (mg/l) | 2.52 | 3.00 | 1.19 | 3.66 | 4.20 | 1.15 | 4.00 | 4.21 | 1.05 | ||
Imatinib | 60-Min I.V. Infusion (100 mg) | Capsule (400 mg) | Oral Solution (400 mg) | Reference | |||||||
Parameters | Observed | Predicted | Ratio | Observed | Predicted | Ratio | Observed | Predicted | Ratio | ||
N | 4 | 4 | 4 | Peng et al., 2004 | |||||||
AUCinf (ng•h/ml) | 7836.00 | 8098.00 | 1.03 | 32640.00 | 30971.88 | 0.95 | 30729.00 | 30971.88 | 1.01 | ||
Cmax (ng/ml) | 1206.00 | 1689.60 | 1.40 | 1822.00 | 1560.67 | 0.86 | 1848.00 | 1539.54 | 0.83 | ||
Oral (100 mg) | Oral (400 mg) | Imatinib (200mg) + Ketoconazole (400mg) | Reference | ||||||||
Parameters | Observed | Predicted | Ratio | Observed | Predicted | Ratio | Observed | Predicted | Ratio | ||
N | 37 | 37 | 14 | Dutreix et al., 2004; Ostrowicz et al., 2014 | |||||||
AUCinf (ng•h/ml) | 6104.00 | 6449.95 | 1.06 | 24304.00 | 27031.78 | 1.11 | 19667.00 | 19801.34 | 1.01 | ||
Cmax (ng/ml) | 370.00 | 354.69 | 0.96 | 1439.00 | 1446.27 | 1.01 | 1213.00 | 866.52 | 0.71 |
AUCinf, AUC from time 0 extrapolated to infinity; AUClast, AUC from time 0 to time of last measurable concentration; N, number of subjects of observed data; Ratio, Predicted/Observed values of AUClast, AUCinf, or Cmax.