TABLE 2

Drug metabolism-related genes whose mRNA is subjected to m6A modification and whose expression is regulated by m6A-related enzymes

Genem6A Modified RegionEffects, m6A-Related Enzymes, Cell LineReference
Evaluation by NGSaEvaluation by RIP with Anti-m6A Antibody
CYP2B63′-UTRNDND
CYP2C8Coding region, 3′-UTRModified in 5′-UTR, coding region, and 3′-UTRDownregulation, METTL3/14; upregulation, FTO; downregulation, YTHDC2, HepaRG and Huh-7 cellsNakano et al., 2020
UGT1ACoding region, intron, 3′-UTRNDND
UGT2B4Coding regionNDND
UGT2B7Not registeredModified in 5′-UTR, coding region, and 3′-UTRDownregulation, METTL3/14; upregulation, FTO and ALKBH5, Huh-7 cellsOndo et al., 2021
UGT2B15Coding regionNDND
UGT2B17IntronNDND
CES15′-UTR, coding regionNDND
CES25′-UTR, coding region, intron, 3′-UTRModified in 5′-UTR, coding region, and 3′-UTRDownregulation, METTL3/14; upregulation by FTO and ALKBH5; downregulation by YTHDC2, HepaRG and Huh-7 cellsTakemoto et al., 2021
AhR5′-UTR, coding region, 3′-UTRNDND
CARCoding region, intron, 3′-UTRNDND
HNF4α3′-UTRModified in 5′-UTR, coding region, and 3′-UTRUpregulation, FTO, Huh-7 cellsOndo et al., 2021
PXRCoding region, 3′-UTRNDND