TABLE 1

Major agonists and antagonists of NRs

Target	Agonist/Antagonist	Drug/Compound	Reference(s)
PXR	Agonist	PCN	Jiang et al., 2019
		Rifampicin	Jiang et al., 2019
		Imazalil	Shizu et al., 2018
		Dexamethasone	Jiao et al., 2020
		Schisandrol B	Zhao et al., 2021
		Mifepristone	Yao et al., 2021
	Antagonist	ET-743	Chai et al., 2020
		Polychlorinated Biphenyls	Mani et al., 2013
		Biphenyls	Mani et al., 2013
		Fluconazole	Mani et al., 2013
		Enilconazole	Mani et al., 2013
		Sesamin	Mani et al., 2013
		Metformin	Mani et al., 2013
PPARα	Agonist	Clofibrate	Lenhard et al., 1999
		WY-14643	Fan et al., 2022
		Gemfibrozil	Lenhard et al., 1999
		Fenofibrate	Willson et al., 2000
	Antagonist	GW6471	Stebbins et al., 2017
		MK886	Stebbins et al., 2017
		NXT629	Stebbins et al., 2017
PPARγ	Agonist	Rosiglitazone	Turmelle et al., 2006
	Agonist	Pioglitazone	Collino et al., 2010
	Antagonist	GW9662	Almahmoud et al., 2021
	Antagonist	T0070907	Almahmoud et al., 2021
CAR	Agonist	CITCO	Tschuor et al., 2016
		Phenobarbital	Huang et al., 2005
		TCPOBOP	Gao et al., 2021
	Antagonist	PK11195	Mackowiak et al., 2019
	Antagonist	CINPA1	Mackowiak et al., 2019
LXR	Agonist	T0901317	Jung et al., 2011
	Agonist	GW3965	Minniti et al., 2020
	Antagonist	GSK2033	Helder et al., 2020
FXR	Agonist	WAY-362450	Wu et al., 2019
	Agonist	OCA	de Haan et al., 2021
	Antagonist	DY268	Jiang et al., 2021
		FLG249	Jiang et al., 2021