TABLE 7

Summary of PK/PD and urinary excretion in rats with and without 5/6 nephrectomy

		Plasma		Liver
siRNA	Condition	C_max	AUC_last	C_max	AUC_last	Urine Excretion	mRNA Reduction
siRNA			μg/ml	h*μg/ml	μg/g	h*μg/g	%
siRNA12	Sham	0.161	0.501	14.5	ND	42 ng/ml^a	74
siRNA12	Nephrectomy	0.131	0.606	14.6	ND	13 ng/ml^a	73
siRNA14	Sham	0.048	0.198	8.0	752	5	70
siRNA14	Nephrectomy	0.034	0.139	5.8	765	0.74	70
siRNA5	Sham	0.080	0.303	11.9	ND	3.2	70
	Nephrectomy	0.081	0.300	14.7	ND	1.1	75

^aTotal urine volume not available for normalization.
ND, not determined.