Pharmacological activity assessment for siRNA2 metabolites (transfected) in plated HEP3B
| Designation (AS) | Target mRNA Baseline Remaining |
|---|---|
| % | |
| Parent | 16.4 |
| 3′N-1 | 10.3 |
| 3′N-2 | 11.4 |
| 3′N-3 | 13.5 |
| 3′N-4 | 15.9 |
| 3′N-5 | 12.2 |
| 3′N-6 | 47.7 |
| 3′N-7 | 81.1 |
| 3′N-8 | 95.7 |
| 5′N-1 | 78.6 |
| 5′N-2 | 20.7 |
| 5′N-3 | 89.0 |
| 5′N-4 | 78.5 |
| 5′N-5 | 95.2 |
| 5′N-6 | 100 |
| 5′N-7 | 100 |
| 5′N-8 | 100 |