TABLE 1

Scaling of CL_int of pevonedistat from recombinent CYPs

CYP	CL_int µl/min/pmol	CYP abundance (pmol/mg)	CL_int^a µl/min/mg	ISEF^b	CL_int L/h	% fm
1A2	0.0744	52	3.87	0.43	13.09	1.4
2B6	0.0835	17	1.42	0.43	4.8	0.5
2C8	0.1040	24	2.5	0.43	8.45	0.9
2C9	0.0599	73	4.37	0.78	26.84	3
2C19	0.0434	14	0.61	0.25	1.2	0.1
2D6	0.0333	8	0.27	0.75	1.8	0.2
3A4/5	3.27	137	448	0.24	846.17	93.5
2J2 (liver)	0.7010	1.2	0.84	0.43	2.85	0.3
2J2 (heart)	0.7010	0.2	0.12	1	0.03
1A1 (lung)	0.3210	38.9^c	12.5	1	1.69

↵^a Measured f_umic of 0.49 was applied.
↵^b The default SimCyp inter-system extrapolation factors (ISEF) for BD-genest supersomes were applied.
↵^c Reported (Kim et al., 2004) and (Delozier et al., 2007).