TABLE 3

Model evaluation for MPH.

				AUC (ng·h/ml)			C_max (ng/ml)
		Dose	N	Mean observed	Mean predicted	PE (%)	Mean observed	Mean predicted	PE (%)
d/dl-MPH
Calibration Datasets
(Midha et al., 2001)		40 mg Ritalin	24	59.1	90.8	53.7	11.7	16.9	45.1
(Midha et al., 2001)		40 mg Ritalin (fed)	24	68.1	103	51.2	14.3	15.6	9.1
(Patrick et al., 2007)		0.3 mg/kg Ritalin	20	82.9	54.5	−34.3	15.3	8.5	−44.4
(Spencer et al., 2006)		40 mg Ritalin	12	81.9^b	97.1	18.5	14.1	15.7	11.3
(Teo et al., 2004)		20 mg Focalin	15	121	96.1	−20.5	23.7	18.1	−23.7
(Teo et al., 2004)		20 mg Focalin (fed)	15	132	99.6	−24.5	22.1	15.5	−30.0
(Patrick et al., 2013)		0.3 mg/kg Ritalin	24	52.1	53.4	2.5	10.1	8.2	−18.8
(Patrick et al., 2013)		0.15 mg/kg Focalin	24	53.7	53.4	−0.6	10.7	8.2	−23.4
(Parasrampuria et al., 2007)		50 mg Ritalin	49	106	125	17.9	21.1	24.0	13.7
(Parasrampuria et al., 2007)		90 mg Ritalin	49	195	226	15.9	38.8	43.2	11.3
Verification Datasets
(Hysek et al., 2014)		60 mg Ritalin	15	175^a	172	−1.9	30.4	32.4	6.6
(Abbas et al., 2016)		40 mg^c Ritalin	29	132	202	52.6	15.6	22.9	46.8
(Adjei et al., 2014)		25 mg^d Ritalin	24	282	188	−33.3	29.1	18.0	−38.1
(DeVane et al., 2000)		10 mg Ritalin	6	23.7^a	19.7	−16.9	4	4.5	12.5
(Koehm et al., 2010)		20 mg Ritalin	9	35	43	22.9	7	7.1	1.4
(Meyer et al., 2000)		20 mg Ritalin	20	35.8	48.9	36.5	7.6	8.8	15.9
(Patrick et al., 1989)		10 mg^e Ritalin	18	42.0	45.3	7.8	6.4	4.8	−25.3
(Spencer et al., 2012)		40 mg^f Ritalin	26	179^a	185	3.3	25.4	22.6	−10.8
(Stage et al., 2017)		10 mg Ritalin	16	21.4^g	23.2^g	18.7	5^g	3.9^g	−19.2
(Wong et al., 1998)		40 mg Ritalin	21	93.6	90.1	−3.7	17.8	16.4	−7.9
Weighted PE (%)						11.7			-0.8
l-MPH
(Wong et al., 1998)	40 mg Ritalin		21	1.51	1.33	−11.9	0.821	0.54	−34.2
(Patrick et al., 2013)	0.3 mg/kg Ritalin		24	0.77	0.72	−6.5	0.18	0.22	22.2
(Patrick et al., 2007)	0.3 mg/kg Ritalin		20	0.82^a^,^b	0.80	−2.4	0.22^b	0.25	13.6
Weighted PE (%)						-7.0			1.3

PK parameters shown as arithmetic mean values unless otherwise noted.
↵^a AUC_0-last
↵^b Obtained from a non-compartmental analysis of digitized population-level data.
↵^c Two doses administered 6 hours apart.
↵^d Three doses administered 4 hours apart.
↵^e Two doses administered 5 hours apart.
↵^f Two doses administered 4 hours apart.
↵^g Values shown as median.