Inhibition of MPH hydrolysis by THC and CBD in time-dependent studies.
| IC50,u (µM) | |||
|---|---|---|---|
| Cannabinoids | Preincubation: 0 min (A) | Preincubation: 30 min (B) | A/B |
| THC | 0.0441 ± 0.0074 | 0.0618 ± 0.0097 | 0.71 |
| CBD | 0.157 ± 0.027 | 0.198 ± 0.029 | 0.79 |
IC50,u, unbound inhibitor concentration that achieves 50% activity. IC50,u values were presented as estimate ± SE (uncertainty) from nonlinear regression analysis using data from a single experiment with three replicate samples.