TABLE 2

Determination of kinetic parameters for inhibition of MPH hydrolysis by THC and CBD.

CannabinoidsKm (µM)Ki,u (µM)αVmax (pmol/min/mg protein)
THC85.7 ± 12.90.031 ± 0.00316.4 ± 14.71056 ± 77
CBD90.6 ± 10.10.091 ± 0.004>9999940 ± 150

  • All values were presented as mean ± S.D. of three independent experiments with duplicate samples.