TABLE 3

The protein abundance of drug transporters in human hepatocytes as measured by targeted proteomics

pmol/mg protein (Mean ± SD)
TransporterLot 8317Lot 8339Lot 8350
OATP1B13.04 ± 0.138.51 ± 0.698.59 ± 0.01
OATP1B30.33 ± 0.11.62 ± 0.631.5 ± 0.08
OATP2B12.21 ± 0.641.4 ± 1.92.74 ± 0.7
NTCP0.18 ± 0.250.41 ± 0.52.11 ± 0.56
OCT12.84 ± 0.083.25 ± 0.192.32 ± 0.13
OAT20.74 ± 0.051.04 ± 0.251.8 ± 0.17
P-gp0.23 ± 0.10.53 ± 0.550.84 ± 0.16
MRP21.15 ± 0.051.09 ± 0.071.96 ± 0.25
Na-K ATPase10.25 ± 1.310.9 ± 0.2710.2 ± 1.9