TABLE 4

Uptake rates of pevonedistat in the presence of 0.5% HSA in plated human hepatocytes

ConditionUptake rate (pmol/min/mg protein)
Lot 8317Lot 8280
4°C37°C4°C37°C
KHB buffer, 37°C0.406 (0.118)2.50 (0.22)0.462 (0.066)2.08 (0.047)
KHB + CsA0.448 (0.034)2.11 (0.209)0.377 (0.092)1.91 (0.108)
Choline, 37°C0.457 (0.034)2.76 (0.125)0.487 (0.109)2.36 (0.139)
Choline + CsA0.352 (0.080)2.43 (0.285)0.404 (0.100)2.70 (0.418)