TABLE 4

Effect of CDCA and RIF on protein expression of liver and jejunum transporters in cynomolgus monkeys

TransporterVehicle50 mg/kg CDCA100 mg/kg CDCA15 mg/kg RIF
fmol/µg proteinfmol/µg proteinp-valuefmol/µg proteinp-valuefmol/µg proteinp-value
OATP1B11.59 ± 0.1170.641 ± 0.322*0.0100.633 ± 0.385*0.0101.14 +0.2760.213
OATP1B31.58 ± 0.1160.580 ± 277*0.0030.604 ± 0.372*0.0040.991 ± 0.1620.051
NTCP0.512 ± 0.1730.366 ± 0.0660.3150.294 ± 0.1160.1030.302 ± 0.0460.115
OCT15.10 ± 0.1956.35 ± 0.2810.0674.49 ± 0.9590.4624.90 ± 0.5120.948
P-gp (MDR1)0.104 ± 0.0240.166 ± 0.0360.3250.244 ± 0.081*0.0181.14 ± 0.0240.765
BCRP0.102 ± 0.0130.201 ± 0.039*0.0020.044 ± 0.016*0.0330.127 ± 0.0070.413
MRP20.850 ± 0.0640.786 ± 0.0440.8940.874 ± 0.1050.9930.721 ± 0.2440.556
BSEP1.40 ± 0.2465.08 ± 1.16*0.0003.32 ± 0.396*0.0161.57 ± 0.2500.976
P-gp (MDR1)0.475 ± 0.1170.310 ± 0.0860.3380.361 ± 0.0540.5991.33 ± 0.208*0.000
BCRP0.261 ± 0.0470.234 ± 0.1400.9670.220 ± 0.0630.9040.318 ± 0.0890.795
MRP20.830 ± 0.2550.823 ± 0.210>0.99990.873 ± 0.2420.9992.08 ± 0.980*0.049
  • Statistics were conducted by one-way ANOVA followed by Dunnett’s multiple comparison method. *p < 0.05 compared with the vehicle group.