TABLE 5

Systemic exposures of CPI, CPIII, and CDCA after the first and multiple administrations of CDCA to cynomolgus monkeys (Day 1 and Day 8, respectively).

Vehicle Control50 mg/kg CDCA100 mg/kg CDCA
AnalyteExposureDay 1Day 8Day 1Day 8Day 1Day 8
CPIAUC0-24h (nM·h)43.5 ± 6.344.5 ± 2.560.6 ± 14.3209 ± 17439.9 ± 11.9151 ± 76.6
Cmax (nM)2.5 ± 0.442.5 ± 0.442.8 ± 0.7414.2 ± 6.7*2.1 ± 0.4811.9 ± 2.3*
CPIIIAUC0-24h (nM·h)17.6 ± 3.513.6 ± 2.118.6 ± 3.8146 ± 1088.1 ± 2.391.0 ± 116
Cmax (nM)1.0 ± 0.360.68 ± 0.180.90 ± 0.176.7 ± 4.40.50 ± 0.165.6 ± 4.5
CDCAAUC0-24h (µM·h)25.0 ± 25.514.6 ± 19.382.4 ± 60.521.9 ± 25.31132 ± 942*1308 ± 540*
Cmax (µM)2.5 ± 2.73.4 ± 4.46.6 ± 2.92.0 ± 1.796.2 ± 55.5*102 ± 68.0*
  • Data represent the mean and S.D. from 3 monkeys; AUC(0-24h), area under plasma concentration-time curve from time 0 to 24 h; Cmax, maximum plasma concentration.

  • Statistics were conducted using one-way ANOVA followed by Dunnett’s multiple comparison method. *p < 0.05 compared with the first vehicle dose (Day 1).