TABLE 2

PBPK simulated AUC0-inf and Cmax values and ratios with and without NN1177 for caffeine and midazolam

MidazolamCaffeine
ScenariosAUC0-inf
(ng*h/ml)
Cmax
(ng/ml)
AUC ratioCmax ratioAUC0-inf
(ng*h/ml)
Cmax
(ng/ml)
AUC ratioCmax
ratio
Before NN1177Baseline22.69.11.01.028,50037501.01.0
After NN1177fu 0.002353.314.22.361.5746,70040001.61.1
fu 0.0131.711.11.401.233,31038801.171.03
fu 0.06424.19.51.071.029,81037801.051.0