TABLE 3

Effects of CDCA on liver gene expression of transporters, enzymes, and nuclear receptors in cynomolgus monkeys

50 mg/kg CDCA100 mg/kg CDCA
Gene NameFold Change (Mean ± SD)p-ValueFold Change (Mean ± S.D.)p-Value
OATP1B10.343 ± 0.233*0.0310.450 + 0.360*0.049
OATP1B30.203 ± 0.227*0.0090.227 ± 0.231*0.010
OATP1B1/30.303 ± 0.259*0.0210.390 ± 0.325*0.037
NTCP0.763 ± 0.2170.6660.813 ± 0.5950.768
MDR11.10 ± 0.1740.8081.38 ± 0.2690.147
BCRP0.580 ± 0.0720.0681.743 ± 0.3160.262
MRP20.400 ± 0.078*0.0070.500 ± 0.261*0.015
MRP30.810 ± 0.1350.2450.797 ± 0.2000.211
MRP41.067 ± 0.3930.99601760 ± 1.750.605
OSTα11.6 ± 7.030.12810.0 ± 7.700.193
OSTβ678 ± 5960.248376 ± 6380.591
CYP3A80.833 ± 0.0570.3350.530 ± 0.1680.054
CYP7A10.002 ± 0.001*0.0420.004 ± 0.003*0.043
UGT1A10.957 ± 0.2240.9390.737 ± 0.1790.204
BAAT0.617 ± 0.1460.3810.723 ± 0.4600.573
ALAS10.853 ± 0.3540.6720.783 ± 0.3320.524
ALAS20.893 ± 0.5360.9470.843 ± 0.6010.891
SHP2.04 ± 0.8500.1581.31 ± 0.5300.783
FXR0.490 ± 0.2270.0880.523 ± 0.3060.108
  • Statistics were conducted by one-way ANOVA followed by Dunnett’s multiple comparison. *p < 0.05 compared with the vehicle group.