fCL by metabolite determined from abrocitinib incubation in human hepatocytes
| Parameter | M1 | M7 | M2/M3 | M4 | 358-1 | 372-1 | 149 | Abrocitinib |
|---|---|---|---|---|---|---|---|---|
| % radioactivity | 5.6 | 0.35 | 4.2 | 3.6 | 0.16 | 0.16 | 0.42 | 85 |
| Metabolite fCL | 0.39 | 0.024 | 0.29 | 0.25 | 0.011 | 0.011 | 0.029 | — |
| Final fCL | 0.41 | 0.29 | 0.27 | 0.029 | — | |||