In vitro enzymatic potency of abrocitinib and human metabolites M1, M2, and M4
| JAK Assay | IC50 (nM)a | |||
|---|---|---|---|---|
| Abrocitinib | M1 | M2 | M4 | |
| JAK1 | 29.2 | 43.4 | 17.9 | >10,000 |
| JAK2 | 803 | 1140 | 886 | >10,000 |
| JAK3 | >10,000 | >10,000 | >10,000 | >10,000 |
| TYK2 | 1250 | 3190 | 1210 | >10,000 |
aIC50 values obtained at 1 mM adenosine triphosphate.