TABLE 1

Summary of the major P450 enzymes involved in the formation of each metabolite

The information of P450s is based on reference Ufer (2005) and Pouncey et al. (2018).

S-Warfarin MetabolitesP450sR-Warfarin MetabolitesP450s
4’-OH-S-warfarin2C19, 3A4, 2C84’-OH-R-warfarin2C19, 3A4, 2C8
6-OH-S-warfarin2C9 (major), 2C19 (minor)6-OH-R-warfarin1A2 (major), 2C19 (minor)
7-OH-S-warfarin2C9 (major), 2C19 (minor)7-OH-R-warfarin2C19, 1A2, 2C8
8-OH-S-warfarin2C198-OH-R-warfarin2C19 (major), 1A2 (minor)
10-OH-S-warfarin3A410-OH-R-warfarin3A4