Placental expression of ABC transporters in response to metabolic disorders
| Disease | Species | Study Size | MDR1/ABCB1 | MRPs/ABCCs | BCRP/ABCG2 | References |
|---|---|---|---|---|---|---|
| Obesity | Mice | N = 6–8 ControlN = 6–8 Obese | ↓ mRNA Abcb1a and protein | NE | NE | (Wang et al., 2015) |
| Human Subjects | N = 20 ControlN = 10 Obese | ↓ mRNA and protein | NE | NE | ||
| Gestational Diabetes Mellitus | Rats | N = 4–5 ControlN = 4–5 Insulin-managed GDM N = 4–5 Non-insulin managed GDM | ↑ mRNA Abcb1b;↔ mRNA Abcb1a(non-insulin managed) | ↑ mRNA Abcc2 (non-insulin managed) | ↑ mRNA(non-insulin managed) | (Anger and Piquette-Miller, 2011) |
| Human Subjects | N = 14 ControlN = 13 GDM | ↑ mRNA | ↔ mRNA ABCC2 | ↔ mRNA | (Anger et al., 2012) |
NE, not examined.