TABLE 2

Pharmacokinetic parameters in healthy and NASH rats administered 12.5 mg/kg OTA

Mean values ± S.D. were compared by unpaired two-tailed Student’s t test where * indicates P < 0.05.

t1/2Cmax/DAUClast/DVz/FCL/FAeAe % of dose
hμg·ml−1·mg−1mg·h·ml−1·mg−1mlml·h−1μg
Control62.46 ± 17.04199.80 ± 79.255.65 ± 1.108.28 ± 1.510.10 ± 0.0324.41 ± 1.745.55 ± 0.37
NASH53.17 ± 19.38196.90 ± 52.517.95 ± 0.61*5.44 ± 0.41*0.08 ± 0.0240.07 ± 9.19*13.11 ± 3.10*
  • Ae, amount excreted into urine over 72 h; AUClast, area under the plasma concentration-time curve measured from 0 to 72 h; CL/F, apparent systemic clearance; Cmax, maximal plasma concentration; D, dose; t1/2, elimination half-life; Vz/F, apparent volume of distribution.