Disease | Species | Study Size | MDR1/ABCB1 | MRPs/ABCCs | BCRP/ABCG2 | References |
---|---|---|---|---|---|---|
Fetal Growth Restriction | Human Subjects | N = 25 controlN = 25 FGR | ↓ mRNA | ↔ mRNAABCC1, -2 | ↓ mRNA | (Evseenko et al., 2007a) |
Human Subjects | N = 18 controlN = 18 FGR | NE | NE | ↓ mRNA and protein | (Cao et al., 2022) | |
Mice | N = 4 controlN = 4 nicotine-induced FGR | ↓ mRNA Abcb1a;↔ mRNA Abcb1b;↓ protein | NE | NE | (Wang et al., 2009) | |
Rats | N = 5 controlN = 5 tobacco/ethanol-induced FGR | ↓ mRNA Abcb1a;↔ mRNA Abcb1b | NE | NE | (Li et al., 2011) | |
Rats | N = 4 controlN = 4 tobacco smoke-induced FGR | ↑ mRNA Abcb1a;↔ mRNA Abcb1b;↑ protein | NE | NE | (Yan et al., 2005) | |
Rats | N = 4 controlN = 4 tobacco-induced FGR | ↑ mRNAAbcb1a | NE | NE | (Yan et al., 2006) | |
Small and Large for Gestational Age | Human Subjects | N = 387 controlN = 130 SGAN = 160 LGA | NE | NE | ↓ mRNA | (Deyssenroth et al., 2017) |
FGR, fetal growth restriction; LGA, large for gestational age; NE, not examined.