TABLE 2

The recovery of the radioactivity in urine and feces of SCID mice and PXB-mice after oral administration of [3H]DS-1971a at 10 mg/kg in the fasted condition.

Excretion pathwayCumulative radioactivity excretion (% of dose)
SCID micePXB-mice
0–24 h0–72 h0–24 h0–72 h
Urine1.6 ± 1.52.6 ± 1.347 ± 6.751 ± 5.9
Feces87 ± 1191 ± 8.239 ± 2.045 ± 0.51
Total (urine + feces)88 ± 9.593 ± 7.086 ± 6.996 ± 5.7
  • Urine and feces were collected up to 72 hours after oral administration of [3H]DS-1971a (10 mg/kg). Each value represents the mean ± SD of 3 mice.