TABLE 1

Descriptions of in vitro parameters in this study

ParametersDescription
CA
Ccell
CB
PSA
Concentration in the buffer at the A side.
Concentration in the cells.
Concentration in the buffer at the B side.
PSa in both directions at the A membrane.
PSBPSa in both directions at the B membrane.
PSPgpPSa for efflux transport by P-gp.
Km,PgpKm of transport by P-gp.
Vmax,PgpVmax of transport by P-gp.
CLMMetabolic clearance by CYP3A4.
PappApparent permeability.
fentUnbound fraction in the cells.
fuUnbound fraction in the incubation buffer.
SASurface area (without microvilli expansion).
VAVolume of the buffer at the A side.
VcellVolume of the cells.
VBVolume of the buffer at the B side.
  • aPermeability surface area product.