Parameters | Description |
---|---|

D | Dose. |

C_{lum,z} | Luminal concentration at z based on the capacity volume. |

C_{ent,z} | Concentration in the epithelial cells at z. |

C_{pro,z} | Concentration in the lamina propria at z. |

[PS]_{A,in,z} | PS^{a} for influx of the A membrane at z. |

[PS]_{A,out,z} | PS^{a} for passive efflux of the A membrane at z. |

[PS]_{Pgp,z} | PS^{a} for efflux transport by P-gp of the A membrane at z. |

[PS]_{B,z} | PS^{a} in both directions of the B membrane at z. |

D_{z} | The dispersion constant at z. |

M_{t}[V] _{lum,z} | Flow rate at time t after dose. |

Capacity volume of the intestinal lumen at z. | |

Hypethetical volume of the inflating water at z. | |

Volume of the epithelial cells at z. | |

Volume of the lamina propria at z. | |

Local blood flow to the lamina propria at z. | |

f_{lum} | Unbound fraction in the intestinal lumen. |

f_{pro} | Unbound fraction in the lamina propria. |

f_{b} | Unbound fraction in the blood. |

R_{HH,z} | Adjustment constant for the uncharged fraction at z based on the Henderson-Hasselbalch equation. |

R_{BL,apical,z} | Ratio between the apical boundary length of the enterocytes at z to the corresponding value of Caco-2 cells. |

R_{BL,basal,z} | Ratio between the basal boundary length of the enterocytes at z to the corresponding value of Caco-2 cells. |

SF_{Pgp} | In vitro to in vivo scaling factor for PS_{Pgp.} |

SF_{CYP3A4} | In vitro to in vivo scaling factor for CL_{M}. |

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^{a}Permeability surface area product.