TABLE 2

Description of in vivo parameters used for ATOM analysis

ParametersDescription
DDose.
Clum,zLuminal concentration at z based on the capacity volume.
Cent,zConcentration in the epithelial cells at z.
Cpro,zConcentration in the lamina propria at z.
[PS]A,in,zPSa for influx of the A membrane at z.
[PS]A,out,zPSa for passive efflux of the A membrane at z.
[PS]Pgp,zPSa for efflux transport by P-gp of the A membrane at z.
[PS]B,zPSa in both directions of the B membrane at z.
DzThe dispersion constant at z.
Mt
[V]lum,z
Flow rate at time t after dose.
Capacity volume of the intestinal lumen at z.
Embedded ImageHypethetical volume of the inflating water at z.
Embedded ImageVolume of the epithelial cells at z.
Embedded ImageVolume of the lamina propria at z.
Embedded ImageLocal blood flow to the lamina propria at z.
 flumUnbound fraction in the intestinal lumen.
 fproUnbound fraction in the lamina propria.
 fbUnbound fraction in the blood.
RHH,zAdjustment constant for the uncharged fraction at z based on the Henderson-Hasselbalch equation.
RBL,apical,zRatio between the apical boundary length of the enterocytes at z to the corresponding value of Caco-2 cells.
RBL,basal,zRatio between the basal boundary length of the enterocytes at z to the corresponding value of Caco-2 cells.
SFPgpIn vitro to in vivo scaling factor for PSPgp.
SFCYP3A4In vitro to in vivo scaling factor for CLM.
  • aPermeability surface area product.