Tissue | P450s | UGTs | NATs /SULTs | References |
---|---|---|---|---|
Kidney | ||||
Proximal Tubule Cells Renal Epithelial Cells | 1B1, 3A4, 3A5, | 1A1, 1A6, 1A8, 1A9, 2B7 1A8, 1A9 | Lash et al., 2008 Van der Hauwaert et al., 2014 | |
Intestines Epithelial Cells Colon Duodenum Ileum Rectum | 2C18, 2J2, 3A5 2C9, 2C19, 2J2, 3A4, 3A5 2C18, 2C19, 2J2, 3A4, 3A5 2C18, 2J2, 3A5 | 1A1, 1A8, 2A3, 2B7 1A1, 1A8, 2A3, 2B7 1A1,1A4, 1A5, 1A8, 1A9, 1A10, 2A3, 2B7, 2B15, 8 1A1, 1A8, 2A3, 2B7 | SULTs 1A1, 1A3, 1A4, 1B1 SULTs 1A1, 1A3, 1A4, 1B1 SULTs 1A1, 1A2, 1A3, 1A4, 1B1, 1C2, 1C3, 1E1, 2A1 SULTs 1A1, 1A3, 1A4, 1B1 | Iswandana et al., 2018 Ho et al., 2017 Riches et al., 2009 Takayama et al., 2021 |
Lung Bronchial Epithelial Cells Parenchymal (alveolar epithelial) Cells | 1B1, 2A7, 2A13, 2B6, 2C8, 2C9, 2C18, 2C19, 2D6, 2E1, 2F1, 2J2, 2R1, 2S1, 2U1, 2W1, 3A5, 3A7 1A1, 1A2, 2A6, 2B6, 2C9, 2C19, 2D6, 2J2, 3A4, 3A5 | 1A1, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9, 1A10, 2A1, 2B4, 2B11, 2B15, 2B17, 2B28, 3A2, 8 1A1, 1A4, 1A6, 2A1, 2B4, 2B7, 2B11 | NAT5, SULTs 1A1, 1A2, 1A3, 1A4, 1B1, 1C2, 1C4, 1E1, 2B1, 4A1 SULTs 1A1, 1A3, 1A4, 1C2, 2A1, 2B1, 2B2 | Courcot et al., 2012 Somers et al., 2007 |
Brain Amygdala Basal Ganglia Cerebellum Cortex Endothelial Cells Hippocampus Medulla Microvasculature Pons Striatum Substantia Nigra Thalamus & Hypothalamus Unspecified Region | 2E1, 2U1 1A1, 1A2, 1B1, 2B6, 2C9, 2C19, 2E1, 3A4, 3A5 1A1, 1A2, 1B1, 2B6, 2C9, 2C19, 2D6, 2E1, 2U1, 3A 1A1, 1A2, 1B1, 2A6, 2B6, 2D6, 2E1, 2U1, 2C9, 2C19, 3A4, 3A5 1A1, 1B1, 2A6, 2B6, 2C9, 2E1, 2J2, 3A4, 4A11 1A1, 1A2, 1B1, 2D6, 2E1, 2C9, 2C19, 2E1, 3A 1B1, 2E1 1B1, 2U1 1A1, 1A2, 2B6, 2D6, 2E1, 3A 1A1, 1A2, 1B1, 2B6, 2D6, 2E1 1A1, 1A2, 1B1, 2D6, 2E1 2D6, 3A4 | 1A6, 2B7 1A1, 1A3, 1A4, 1A6, 1A9, 2A3, 2B4, 2B7, 2B10, 2B11, 2B15, 2B17, 2B28 | SULTs 1A1, 1A3 SULTs 1A1, 1A3, 4A1 SULTs 1A1, 1A3 | Court et al., 2012 Ghosh et al., 2010 Jones and Lazarus, 2014 King et al., 1999 Kuban and Daniel, 2021 McFayden et al., 1998 Salman et al., 2009 Shawahna et al., 2011 Toselli et al., 2015 |