TABLE 6

Summary of the percent contribution of individual UGT isoforms responsible for the formation of M7 following incubation with AZD4831 in recombinantly expressed UGTs

Isoform	Control Substrate	Relative Contribution (%) Among the Seven Tested UGT Isoforms to the Formation of M7
UGT1A1	β-Estradiol	96
UGT1A3	4-Methyl umbelliferone	0.64
UGT1A4	Lamotrigine	NC^a
UGT1A6	1-Naphthol	NC^a
UGT1A9	Propofol	1.3
UGT2B7	Zidovudine	2.3
UGT2B15	Oxazepam	NC^a

NC, not calculated.
^aBelow limit of detection with signal-to-noise ratio < 3.